Exposure to secondhand smoke and risk of TB

Lin, H.H., Chiang, Y.T., Chuang, J.H., Yang, S.L., Chang, H.Y., Ezzati, M. and Murray, M., 2013. Exposure to secondhand smoke and risk of tuberculosis: prospective cohort study. PloS one, 8(10), p.e77333.
  • After adjusting for potential confounders, no association was found between secondhand smoke exposure and active TB.
  • No significant association was found between secondhand smoke and TB in the overall study population.
  • Subgroup analysis indicated that adolescents and young adults might be particularly vulnerable to the effects of secondhand smoke on TB.
  • The immune response related to TB protection, such as macrophage function and the IL-12/IFN-gamma circuit, matures in adolescence and should be similar across all age groups in the study.
  • One hypothesis for differential susceptibility is that tobacco smoke might increase the risk of primary progression rather than reactivation from remote infection.
  • The increased relative risk in adolescents suggests that the hazard of tobacco smoke is mediated through primary progression rather than remote reactivation.

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