Explaining age disparities in tuberculosis burden in Taiwan

Fu, H., Lin, HH., Hallett, T.B. et al. Explaining age disparities in tuberculosis burden in Taiwan: a modelling study. BMC Infect Dis 20, 191 (2020). https://doi.org/10.1186/s12879-020-4914-2

  • Increasing Need for TB Control Among Elderly: As countries near TB elimination goals, prioritizing TB control measures for the elderly becomes critical due to age disparities in TB burden.
  • Immune Senescence: Older individuals with latent TB infections are at higher risk of developing active TB as their immune systems weaken with age.
  • Declining Transmission: TB transmission has significantly decreased in recent decades due to improved living conditions and health services, with older generations more likely exposed to TB.
  • Age-specific Assortativity: Elders primarily interact within their own age group, leading to TB infections that rarely spread to younger people.
  • Control Strategies: Focus on preventing disease progression in the elderly by addressing immune senescence and controlling transmission through age-specific approaches.
  • Dominant Mechanism: Immune senescence is a more significant factor in age-related TB disparities than age-specific assortativity.

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